petlab@hust

教授

 




 

谢庆国

一、基本资料
华中科技大学、武汉光电国家实验室(筹)教授,国家杰出青年科学基金获得者。全数字PET的发明人。专注于正电子发射断层成像(Positron Emission Tomography,简称PET)方法研究和仪器研制。2001年在华中科技大学创立了数字PET实验室,提出了多电压阈值采样法(MVT),解决了高速脉冲精确数字化的难题。以此为基础,系统性地发展了全数字、模块化的PET探测器技术,建立起完整、系统的全数字PET技术基础,有望引领数字PET领域仪器研发与应用创新。2001年在华中科技大学创立了数字PET实验室,逐渐形成人才培养平台、技术创新平台和产业化支撑社会服务平台。从教以来他指导了华中科技大学、武汉大学、东北大学、四川大学等校70余名本科生进入实验室进行科研训练,指导(过)硕士生50余名、博士生10余名。

二、学术经历

1994年获华中理工大学自动控制工程系工业自动化学士学位

1997年获大连理工大学电子系工业自动化硕士学位

2001年获华中科技大学控制科学与工程系控制理论与控制工程博士学位

1997年至2005年,控制科学与工程系

2005年至今,生命科学与技术学院、武汉光电国家实验室(筹)

2002年至2004年,台湾卫生研究院医学工程研究组

2006年至2008年,芝加哥大学放射学系、Argonne国家实验室高能物理研究组

三、研究方向

研究方向为PET系统开发(PET探测器、PET电子学、PET图像重建、PET系统集成与评估)、PET/CT成像技术与应用、PET/MRI成像技术与应用、多模医学图像处理。

四、科研项目

主要研究方向为PET系统开发(探测器、电子学、图像重建、系统集成与评估)、PET成像技术与应用、多模医学图像处理。

近年来主持国家重大科学仪器设备开发专项、国家科技支撑计划子项目、国家自然科学基金青年基金项目、国家自然科学基金重大国际合作项目、国家自然科学基金科学仪器专项、国家 863探索导向计划项目、中俄政府间科技合作项目、科技部国际合作重点项目和国家自然科学基金面上项目等国家级项目10余项,在本领域顶尖国际会议做PET仪器有关的口头报告和墙报报告多次;受邀在中国工程院、中科院苏州生物医学工程研究所、中科院近代物理研究所、美国国立卫生研究院等单位进行PET关键技术研发的相关学术报告。

提出的高速脉冲数字化方法和技术,在PET领域实现了技术突破。一方面为打破国外技术垄断提供了条件,对实现技术转型突破,推动我国大型医疗器械产业的跨越式发展,带动相关产业(如上游的稀土的高端应用、核心光电器件、高端电压电源、高速数据采集装置、机械制造、电子电路及IC设计等和下游的医药产业等)的协同优化与升级提供助力;另一方面可能为我国的生命科学研究提供全新的关键科学仪器支持,极大促进生物医药和临床诊疗水平的发展,并提升我国的医疗服务水平,为我国人口健康重大民生工作做出贡献。

五、发明专利

作为第一发明人获得中美德日等国际国内专利授权30余件。作为第一发明人获得美国发明专利授权两件,德国发明专利授权一件,中国台湾发明专利授权一件。作为第一发明人或所指导学生作为第一发明人,正在申请或公开发表中国或国际发明专利多件。

六、学术著作 http://wiki.mdaxue.com/doc-view-842258.html

发表论文30余篇,其中在IEEE Transactions on Nuclear Science、Nuclear Instruments and Methods in Physics Research A、IEEE NSS、IEEE MIC等本领域权威杂志和会议发表和录用论文近20篇。

代表性论文:

[1]BaichengLi, Yue Wang, Daoming Xi, Chenhui Li, Chen Zeng, Ruiheng Wang, Kun Liang, Ru Yang, Qingguo Xie, Dejun Han. "Feasibility Study on Silicon Photomultiplier with Epitaxial Quenching Resistors as the Readout for PET Detectors." IEEE Transactionson Nuclear Science 63, no. 11 (2016): 17-21.

[2]YanzhaoLi, Peng Xiao, Xiaohua Zhu, Qingguo Xie. "Multi-Resolution Multi-Sensitivity Design for Parallel-Hole SPECT Collimators." Physics in Medicine and Biology 61, no. 14 (2016): 5390-405.

[3]Mohamed A. A. Ahmed, Peng Xiao, Qingguo Xie. "New Approach for Simultaneous Respiratory and Cardiac Motion Correction in Cardiac PET (NAMC-CPET)." Physics in Medicine and Biology 60, no. 19 (2015): 7779-804.

[4]XiaoqingCao, Qingguo Xie, Peng Xiao. "A Regularized Relaxed Ordered Subset List-Mode Reconstruction Algorithm and its Preliminary Application to Undersampling PET Imaging." Physics in Medicine and Biology 60, no. 1 (2015): 49-66.

[5]Zhenzhou Deng, Qingguo Xie. "Quadratic Programming Time Pickoff Method for Multivoltage Threshold Digitizer in PET." IEEE Transactionson Nuclear Science 62, no. 31 (2015): 805-13.

[6] N. D’Ascenzo, P.S. Marrocchesi, C.S. Moon, F. Morsani, L. Ratti, V. Saveliev, A. Savoy Navarro and Qingguo Xie, Silicon avalanche pixel sensor for high precision tracking, Journal of Instrumentation, 2014 (accepted)

[7] Jinxia Guo, Lixin Lang, Shuo Hu, Ning Guo, Lei Zhu, Zhongchan Sun, Ying Ma, Dale O. Kiesewetter, Gang Niu, Qingguo Xie and Xiaoyuan Chen, Comparison of three dimeric 18F-AIF-NOTA-RGD tracers, Molecular Imaging and Biology, vol. 16, pp. 274-283, 2014

[8] Jinxia Guo, Ning Guo, Lixin Lang, Dale O. Kiesewetter, Qingguo Xie, Quanzheng Li, Henry S. Eden, Gang Niu and Xiaoyuan Chen, 18F-Alfatide II and 18F-FDG dual-tracer dynamic PET for parametric, early prediction of tumor response to therapy, Journal of Nuclear Medicine, vol. 55, pp. 154-160, 2014

[9] Qingguo Xie, Lu Wan, Xiaoqing Cao and Peng Xiao, Conceptual design and simulation study of an ROI-focused panel-PET scanner, PLoS One, vol. 8, no. 8, pp. e72109, 2013

[10] Peng Xiao, Xiaoqing Cao, Lu Wan and Qingguo Xie, TOF capability evaluation on a panel PET for human body imaging, Journal of Instrumentation, vol. 8, no. 4, pp. P04001, 2013

[11] Weixing Wan, Ning Guo, Donghui Pan, Chunjing Yu, Yuan Weng, Shineng Luo, Hong Ding, Yuping Xu, Lizhen Wang, Lixin Lang, Qingguo Xie, Min Yang and Xiaoyuan Chen, First experience of 18F-Alfatide in lung cancer patients using a new-lyophilized kit for rapid radiofluorination, Journal of Nuclear and Medicine, vol. 54 , pp. 691-698, 2013

[12] Zhenzhou Deng, Qingguo Xie, Zhiwen Duan and Peng Xiao, Scintillation event energy measurement via a pulse model based iterative deconvolution method, Physics in Medicine and Biology, vol. 58, pp. 7815-7827, 2013

[13] Luyao Wang, Jun Zhu, Xiao Liang, Ming Niu, Xiaoke Wu, Chien-Min Kao, Heejong Kim, Qingguo Xie. "Performance Evaluation of the Trans-PET (R) BioCaliburn (R) LH System: A Large FOV Small-Animal PET System." Physics in Medicine and Biology 60, no. 1 (2015): 137-50.

[14] Chunhui Zhang, Xueli Chen, Shouping Zhu, Lu Wan, Qingguo Xie, Jimin Liang. "Performance Evaluation of a 90 Degrees-Rotating Dual-Head Small Animal PET System." Physics in Medicine and Biology 60, no. 15 (2015): 5873-90.

[15]Jingjing Liu, Chien-Min Kao, Shuguo Gu, Peng Xiao, Qingguo Xie. "A PET System Design by Using Mixed Detectors: Resolution Properties." Physics in Medicine and Biology 59, no. 13 (2014): 3517-32.

[16] Daoming Xi, Chien-Min Kao, Wei Liu, Chen Zeng, Xiang Liu and Qingguo Xie, FPGA-only MVT digitizer for TOF PET, IEEE Transactions on Nuclear Science, vol. 60, no. 5, pp. 3253-3261, 2013

[17] Qingguo Xie, Yuanbao Chen, Jun Zhu, Jingjing Liu, Xi Wang, Xin Chen, Ming Niu, Zhongyi Wu, Daoming Xi, Luyao Wang, Peng Xiao, Chin-Tu Chen and Chien-Min Kao, Implementation of LYSO/PSPMT block detector with all digital DAQ system, IEEE Transactions on Nuclear Science, vol. 60, no. 3, pp. 1487-1494, 2013

[18] Xi Wang, Qingguo Xie, Yuanbao Chen and Ming Niu, Advantages of digitally sampling scintillation pulses in pileup processing in PET, IEEE Transactions on Nuclear Science, vol. 59, no. 3, pp. 498-506, 2012

[19] Ming Niu, Chien-Min Kao, Jun Zhu, Peng Xiao, Anwen Long, Robert G. Wagner, Gary Drake, Chin-Tu Chen and Qingguo Xie, Evaluation of multi-pixel photon counters in energy determination for PET imaging, Journal of Instrumentation, vol. 7, no. 4, pp. T04001, 2012

[20] Jing Zhong, Wenzhong Liu, Zhongzhou Du, Paulo Cesar de Morais, Qing Xiang and Qingguo Xie, A noninvasive, remote and precise methodfor temperature and concentration estimation using magnetic nanoparticles, Nanotechnology, vol. 23, no. 3, pp. 075703, 2012.

[21] Ning Guo, Lixin Lang, Haokao Gao, Gang Niu, Dale O. Kiesewetter,Qingguo Xie and Xiaoyuan Chen, Quantitative analysis and parametric imaging of 18F-Labeled monomeric and dimeric RGD peptides using compartment model, Molecular Imaging and Biology, vol. 14, no. 6, pp. 743-752, 2012.

[22] Ning Guo, Linxin Lang, Weihua Li, Dale O. Kiesewetter, Haokao Gao, Gang Niu, Qingguo Xie and Xiaoyuan Chen, Quantitative analysis andcomparison study of [18F] AlF-NOTA-PRGD2, [18F] FPPRGD2 and [68Ga] Ga-NOTA-PRGD2 using a reference tissue model, PLoS One, vol. 7, no. 5, pp. e37506, 2012

[23] Daoming Xi, Qingguo Xie, Jun Zhu, Li Lin, Ming Niu, Peng Xiao, Chin-Tu Chen and Chein-Min Kao, Optimization of the SiPM pixel size for a monolithic PET detector, Physics Procedia, vol. 37, pp. 1497-1503, 2012

[24] Jingjing Liu and Qingguo Xie, "An investigation of local high spatial resolution adaptive PET system," Engineering Sciences. vol. 13, no. 10, pp 105-112, 2011

[25] Jinxia Guo, Xiaoqing Cao, and Qingguo Xie, "Preliminary investigation of relation between PET geometric and system response matrix," Nuclear Electronics and Detection Technology, vol. 31, no. 1, pp. 62-66, 2011

[26] Zhenzhou Deng, Zhiwen Duan, Jingjing Liu, and Qingguo Xie, "Incomplete data CT image reconstruction based on a new scanning mode," Nuclear Electronics and Detection Technology, vol. 31, no. 1, pp. 62-66, 2011

[27] Qingguo Xie, Chien-Min Kao, Xi Wang, Ning Guo, Caigang Zhu, Henry Frisch, William W. Moses, and Chin-Tu Chen, “Potentials of digitally sampling scintillation pulses in timing determination in PET,” IEEE Transactions on Nuclear Science, vol. 56, No. 5, pp. 2607-2613, 2009.

[28] Chien-Min Kao, Qingguo Xie, Yun Dong, Lu Wan, and Chin-Tu Chen, “Development and performance evaluation of a high-sensitivity positron emission tomography scanner dedicated for small-animal imaging,” IEEE Transactions on Nuclear Science, vol. 56, No. 5, pp.2678-2688, 2009.

[29] Heejong Kim , Chien-Min Kao, Qingguo Xie, Henry Frisch, Chin-TuChen, and Fukun Tang, "A multi-threshold method for TOF PET signal processing," Nucl. Inst. and Meth. in Phys. Res. Sect. A, vol. 602, pp. 618-621, 2009

[30] Qingguo Xie, Chien-Min Kao, Zekai Hsiau, and Chin-Tu Chen, “A new approach for pulse processing in Positron Emission Tomography,” IEEE Transactions on Nuclear Science, vol. 52, No. 4, pp988-995, 2005

[31] Zhonghua Deng, Qingguo Xie, “DSP based hardware design of all-digital AC variable speed system,” International Journal Hydroelectric Energy, vol. 23, No. 2, pp55-57, 63, 2005

[32]  Qingguo Xie, Shuyun Wan and Jin Zhao, “A systemic design methodology of T-S fuzzy controller”, Electrical Drive, vol. 33, No. 2, pp. 25-27, 62, 2003

[33] Qingguo Xie, Jin Zhao, Shuyun Wan and Yi Shen, “On stability analysis of induction motor”, Control Theory and Application, vol. 19, No. 6, pp. 919-202, 2002

[34] Qingguo Xie, Jin Zhao, Yi Shen and Shuyun Wan, “Speed sensorless control of induction motor using soft-computing methodologies”, Electrical Drive, vol. 32, No. 4, pp. 20- 24, 2002

[35] Qingguo Xie, Yi Shen and Shuyun Wan, “On convergence analysis of Elman neural network”, Computer Engineering and Application, vol.38, No.6, pp65-66, 81, 2002

[36] Qingguo Xie, Song Min, Shuyun Wan and Jin Zhao, “Software design of all digital AC variable speed system”, Computer Engineering and Application, vol.38, No.5, pp207-210, 2002

[37] Qingguo Xie, Shuyun Wan and Jin Zhao, “A systemic design methodology of Elman recurrent network”, Journal of HUST, vol.30, No.3, pp22-24, 2002

[38] Qingguo Xie, Jin Zhao, Shuyun Wan, and Anwen Shen, “An encryption algorithm based on chaotic iteration”, Journal of China Three Gorges University, vol.24, No.2, pp137-138, 2002

[39] Qingguo Xie, Shuyun Wan, Yanchun Yi, Jin Zhao, and Yi Shen, “Speed sensorless control using Elman neural network”, System Engineering and Electronics, vol. 12, No.4, pp. 53-58, 2001

[40] Kee Zeng, Qingguo Xie, Yi Shen, and Shuyun Wan, “Design ideology of component technology-based energy management system”, Electrical Power System Automation, Vol. 25, No. 9, pp.35-37, May 2001

[41] Kee Zeng, Qingguo Xie, Zheng Yang, and Changguo Ke, “Component technology-based electrical power system MIS model”, International Journal Hydroelectric Energy, Vol. 19, No. 1, pp. 75-76, Mar. 2001

[42] Qingguo Xie, Zhonghua Deng, Shuyun Wan, and Jin Zhao, “Modified LIUS algorithm and implementation with DSP”, Computer Engineering and Application, Vol. 37, No. 5, pp.100-101, 125, Feb. 2001

[43] Qingguo Xie, Shuyun Wan, Jin Zhao, and Zhiguo Li, “Phase compensation for direct torque control using fuzzy inference,” International Journal Hydroelectric Energy, Vol. 18, No. 3, pp. 69-72, Sept. 2000

[44] Qingguo Xie, Zhonghua Deng, and Shuyun Wan, “Communication between DSP-based high-speed control system and IBM-PC,” Electrical Drive Automation, Vol. 22, No. 5, pp. 36-38, 58, Sept. 2000

[45] Qingguo Xie, Jin Zhao, Shuyun Wan, and Lijiu Wang, “DSP-based all digital AC drive system,” Electrical Automation, Vol. 22, No. 3, pp. 29-30, May 2000

[46] Kee Zeng, Qingguo Xie, Zhonghua Deng, and Shuyun Wan, “Enhanced RSA algorithms implemented with DSP,” Computer Engineering and Application, Vol. 36, No. 8, pp.68-69, 79, Aug. 2000

[47] Kee Zeng, Qingguo Xie, Yuli Fu, and Shuyun Wan, “An adaptive fuzzy controller for central heating net,” Journal of HUST, Vol. 28, No. 3, Mar. 2000

[48] Qingguo Xie, Hong Gu, Jianhua Yang, and Yinmin Liu “Discussion of Windows as a real-time control platform,” Computer Engineering and Application, Vol. 34, No. 8, 1998

[49] Qingguo Xie, Zhonghua Deng, and Shanmei Cheng, “Application interface design of Intel82530 in high-speed control systems based on TMS32020,” Electrical Drive Automation, Vol. 19, No. 1, 1997

获得荣誉

先后获得国家自然科学基金青年基金(2006)、湖北省杰出青年基金(2009)、国家杰出青年基金(2014)项目资助,入选教育部“新世纪优秀人才支持计划”(2009)、科学中国人年度人物(2012),并荣获湖北省技术发明一等奖(2013)、发展的“辐射探测与成像”相关产品获第41届日内瓦国际发明展金奖。

联系方式

邮箱:qgxie@mail.hust.edu.cn



 
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